SRM or stem-cell released molecules are a technology made by a company called BioRegenerative Sciences, licensed exclusively to NeoGenesis. S2RM technology is the use of more than one stem cell. The SRM technology includes identifying stem cells involved in wound healing, and then culturing and stimulating these stem cells in order to secrete specific molecules which are naturally packed in organelles called exosomes.
- The in vitro evidence suggests that stem cell exosomes promote cell growth and migration of dermal papilla cells whilst reducing cell death (apoptosis).
- The in vivo (in mice) evidence suggests that stem cell exosome subcutaneous injection may increase hair growth, however, the mice the researchers used were at different age ranges and therefore different stages of the hair cycle. This may lead to varying results or hair growth independent of treatment. Combined treatment of stem cell exosomes and minoxidil appeared to show the most improvement regarding hair regrowth.
- There is very little actual clinical data supporting this product, however, there was a study published in which the topical NeoGenesis serum (which contains S2RM) was combined with microneedling with 13 participants (10 men and 3 women) aged between 28-64. 1 ml of serum was applied twice a day for 24 weeks, and the scalp was also microneedled every 2 weeks during a visit to a trichologist. 12 out of 13 patients showed significant hair growth, and 9 out of 12 participants showed increases in hair thickness by the end of the 24-week period. However, the issues associated with this study include a small sample size, no placebo group, no S2RM monotherapy, and no statistics conducted. Furthermore, the study was conducted by a professional partner of NeoGenesis and co-authored by a doctor who was a lead scientist for NeoGenesis, which presents a conflict of interest as they have “skin in the game” and subsequently may be biased.
- Our experience tracking members: S2RM by itself is not enough to improve hair loss outcomes.