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Rob (PHH)

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Flutamide is a powerful anti-androgenic drug that is typically used to treat prostate cancer in men. However, it is sometimes prescribed as an off-label treatment for female pattern hair loss.

Key insights:

  • The in vitro evidence suggests flutamide has potent antiandrogen activity, which can benefit patients with androgenetic alopecia.
  • The clinical evidence suggests that at doses of 62.5 mg/day, small-scale studies suggest that oral flutamide is well-tolerated and can lead to impressive sustainable hair regrowth in women – even over 4-8 year periods of use. Furthermore, flutamide appears to be particularly beneficial for women with female pattern hair loss who also have other signs of androgen dominance like high testosterone and/or dihydrotestosterone levels, hirsutism (unwanted facial hair), or signs of androgen-driven polycystic ovarian syndrome.
  • Flutamide use comes with a risk of liver damage (hepatotoxicity). In clinical studies on flutamide for pattern hair loss, 4% to 15% of users either showed liver test abnormalities during usage or had to drop out because of side effects. Therefore, tracking liver enzymes during flutamide use is of utmost importance.
  • If you decide to try flutamide, you can get it on prescription from your doctor. 
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